Clinical Study on Minchuanke Granules Combined with Conventional Western Medicine for the Treatment of Allergic Rhinitis-Asthma Syndrome
10.19879/j.cnki.1005-5304.202405439
- VernacularTitle:敏喘克颗粒联合常规西药治疗变应性鼻炎-哮喘综合征临床研究
- Author:
Hong GUO
1
;
Jie XIAO
;
Yueyang ZHANG
Author Information
1. 天津市滨海新区中医医院,天津 300451
- Keywords:
Minchuanke Granules;
allergic rhinitis-asthma syndrome;
clinical study
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(11):142-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of Minchuanke Granules combined with conventional Western medicine in the treatment of allergic rhinitis-asthma syndrome(CARAS);To explore the mechanism of its efficacy.Methods Totally 69 patients with CARAS were divided into 34 cases in the control group and 35 cases in the treatment group using random number table method.Both groups were given oral theophylline extended-release tablets and topical budesonide nasal spray.The treatment group was given Minchuanke Granules on the basis of the control group,one dosage per day,twice a day,orally.30 d was one treatment course for both groups,and two courses were observed.Asthma control efficacy and clinical efficacy were observed.TCM symptom scores and sign scores,serum IgE,interleukin(IL)-4,IL-33,γ interferon(IFN-γ),and tumor necrosis factor-α(TNF-α)levels before and after treatment in two groups were compared.Safety indicators and adverse reactions of both groups were monitored.Results Two Cases were lost in each group.The total effective rate of asthma control in the treatment group was 87.88%(29/33),while in the control group it was 65.63%(21/32),without statistical significance(P>0.05).The total effective rate of clinical efficacy in the treatment group was 87.88%(29/33),while that in the control group was 56.25%(18/32),with statistical significance(P<0.05).Compared with before treatment,the total score of TCM symptoms decreased in both groups after treatment(P<0.05);after treatment,the total score of TCM symptoms in the treatment group was lower than that in the control group(P<0.05).Compared with before treatment,there was no statistically significant difference in nasal congestion,itching,runny nose,cough,wheezing,shortness of breath and chest tightness of the two groups after treatment(P>0.05);after treatment,there was no statistical significance(P>0.05)in the grading of the above symptoms in the treatment group.Compared with before treatment,the serum IgE,IL-4,and IL-33 levels in the treatment group significantly decreased after treatment,while TNF-α and IFN-γ levels significantly increased(P<0.05);after treatment,the treatment group showed better improvement in IgE,IL-4,IL-33,TNF-α,and IFN-γ compared to the control group(P<0.05).There were no significant abnormalities in the safety indicators of the two groups,and no obvious adverse reactions were observed.Conclusion Minchuanke Granules combined with conventional Western medicine can effectively improve the clinical symptoms of CARAS patients by lowering IgE,regulating Th1/Th2 levels,and inhibiting the release of inflammatory mediators,thereby exerting the effects of treating CARAS.
