Effects of Baihe Gujin Decoction on the Long-term Prognosis of NSCLC Patients with Radiotherapy Based on Real World
10.19879/j.cnki.1005-5304.202403118
- VernacularTitle:基于真实世界的百合固金汤对非小细胞肺癌放疗患者长期预后的影响
- Author:
Xinying ZHENG
1
;
Huiyong ZHANG
;
Xing HUANG
;
Lei QIU
;
Qingliang FANG
;
Zhenhui LU
;
Lei WANG
Author Information
1. 上海中医药大学附属龙华医院,上海 200032
- Keywords:
real-world research;
non-small cell lung cancer;
radiotherapy;
Baihe Gujin Decoction;
survival
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(10):142-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of Baihe Gujin Decoction on long-term survival in patients with non-small cell lung cancer(NSCLC)receiving radiotherapy(RT)in the real world.Methods Retrospective data from patients with NSCLC receiving RT in the Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine(TCM)and data from patients in the Surveillance,Epidemiology and End Results(SEER)database were collected and grouped as the TCM+conventional Western medicine(CWM)cohort and CWM cohort,respectively.Propensity score matching(PSM)was used to balance confounders between groups.Kaplan-Meier curve and Cox regression model were used to estimate the effects of Baihe Gujin Decoction on survival outcomes of patients receiving RT.Results Totally 190 samples with a balance between groups were obtained using PSM.Overall survival(OS)analysis showed that the TCM+CWM cohort had significantly longer OS than the CWM cohort(P=0.004).Subgroup analysis showed that the Baihe Gujin Decoction was more advantageous in the characteristic population of age≥65 years(P=0.027),male(P=0.010),T3-T4 stage(P<0.001),N2-N3 stage(P=0.026),M1 stage(P<0.001),not receiving chemotherapy(P<0.001),and not undergoing surgery(P<0.001).Multivariate Cox regression confirmed that treatment group(P=0.003),T(P=0.003)and M stages(P=0.002)may be the independent prognostic factors for OS of NSCLC patients treated with RT.Conclusion Baihe Gujin Decoction probably can improve the long-term prognosis in NSCLC patients treatment with RT.
