Evaluation on Key Production Process of Jiangshi Granules Based on Fingerprint and Quantity-Value Transfer Relationship
10.19879/j.cnki.1005-5304.202405134
- VernacularTitle:基于指纹图谱和量值传递关系评价姜石颗粒关键生产工艺
- Author:
Hongwei ZHANG
1
;
Wenfei DANG
;
Jingjing ZHOU
;
Jie ZHOU
;
Ziming JIN
;
Xia DOU
Author Information
1. 甘肃中医药大学药学院,甘肃 兰州 730000
- Keywords:
Jiangshi Granules;
fingerprint;
production process;
content determination;
transport rate;
value dissemination
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(10):135-141
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the key production process of Jiangshi Granules based on the new mode of combining fingerprint and quantity-value transfer relationship.Methods The fingerprints of Jiangshi Granules extract,extractum and granules were established by HPLC.The common peak transfer number of the fingerprint,the calculation of multi-component content transfer rate,and the paste rate were set as indicators to analyze the quantity and mass transfer law in the production process.The rationality of the preparation process design of Jiangshi Granules was evaluated.Results The fingerprints of 10 batches of Jiangshi Granules extract,extractum and granules were established.17 common peaks were calibrated and 8 peaks were identified.They were respectively tangshenoside I,liquiritin,lobetyolin,isoliquiritin apioside,isoliquiritin,liquiritigenin,glycyrrhizic acid,atractylenolide Ⅲ;the average transfer rates of 8 components from decoction pieces to extract were 29.42%,51.26%,23.81%,34.45%,28.29%,30.22%,42.67%,26.10%;the average transfer rates of extract to extractum were 50.05%,60.04%,51.04%,50.27%,47.60%,52.44%,53.44%,44.97%;the average transfer rates of extractum to granules were 64.83%,78.74%,70.16%,66.56%,70.62%,69.59%,76.97%,66.43%.Conclusion The established fingerprint of Jiangshi Granules extract,extractum and granules is stable and reliable,which emphasizes the integrity of the research process of TCM preparations and provides a basis for the quality control of Jiangshi Granules in the production process.
