Discussion on the Effects of Macrophage Polarization on Diabetic Kidney Disease Based on TCM Yin-yang Theory
10.19879/j.cnki.1005-5304.202403054
- VernacularTitle:基于中医阴阳学说探讨巨噬细胞极化在糖尿病肾脏疾病中的作用
- Author:
Lingling ZHU
1
,
2
;
Ying TAN
;
Yun SHE
;
Jiangyi YU
;
Qianhua YAN
Author Information
1. 南京中医药大学附属医院,江苏 南京 210029
2. 南京中医药大学,江苏 南京 210023
- Keywords:
macrophage polarization;
diabetic kidney disease;
yin-yang theory
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(10):19-23
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease(DKD)is one of the serious microvascular complications of diabetes.Immune disorder-mediated chronic inflammation is an essential mechanism underlying the occurrence of DKD.Macrophages,as important participants in the immune-inflammatory response,can polarize into the pro-inflammatory M1 phenotype and anti-inflammatory M2 phenotype under different microenvironments.The two are functionally antagonistic to each other.They can be transformed into each other in different developmental stages of DKD,which is similar to the connotation of yin and yang in the theory of"yin-yang theory"in TCM,such as restriction of opposites,mutual root and mutual use,balance of growth and decline,and mutual transformation.The imbalance of M1 and M2 macrophages is an important factor leading to DKD inflammatory response and renal fibrosis.Therefore,based on the yin-yang theory in TCM,this article clarified the effects of macrophage polarization on DKD,and proposed that the basic treatment method is to"tonify deficiency and damage excess"to adjust the polarization of macrophages and restore the balance of yin and yang,in order to provide ideas for the clinical treatment of DKD.
