Research Progress in the Regulation of TCM for Autophagy in the Treatment of IgA Nephropathy
10.19879/j.cnki.1005-5304.202310001
- VernacularTitle:中药调控自噬治疗IgA肾病研究进展
- Author:
Yu CHEN
1
;
Guodong HUANG
;
Ting QIN
;
Zechao ZHANG
;
Huiling WANG
;
Shaofang LIU
;
Chao MO
Author Information
1. 广西中医药大学附属国际壮医医院,广西 南宁 530000
- Keywords:
IgA nephropathy;
autophagy;
TCM;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(9):185-190
- CountryChina
- Language:Chinese
-
Abstract:
IgA nephropathy is a common primary glomerular disease,and autophagy plays an important role in maintaining the homeostasis of the internal environment.Dysfunction of cellular autophagy can affect the occurrence and development of IgA nephropathy.This article focused on the molecular mechanism of TCM regulating autophagy in renal intrinsic cells,and found that TCM extracts and formulas mainly regulate autophagy through PI3K/Akt/mTOR,TLR4/NF-κB,MAPK,Nrf2/HO-1,NLRP3 and other signaling pathways.Furthermore,it could intervene in pathological damage such as renal fibrosis,inflammation,and oxidative stress,delaying the progression of IgA nephropathy,in order to provide reference for the clinical treatment and new drug development of IgA nephropathy.
