Research Progress in Chinese Materia Medica Regulation of Glucose Metabolism Reprogramming Intervention in Gastric Precancerous Lesions Based on Hypoxia Microenvironment
10.19879/j.cnki.1005-5304.202309504
- VernacularTitle:中药基于缺氧微环境调控糖代谢重编程干预胃癌前病变研究进展
- Author:
Xiaolong WANG
1
;
Ruiping SONG
;
Pengcheng DOU
;
Zhuangzhuang FENG
;
Xiaowei SUN
;
Dongxu LEI
;
Jing YANG
;
Qingshan NAN
;
Jin SHU
Author Information
1. 甘肃中医药大学,甘肃 兰州 730000
- Keywords:
precancerous lesions of gastric cancer;
hypoxic microenvironment;
glucose metabolism reprogramming;
glycolysis;
Chinese materia medica
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(9):179-184
- CountryChina
- Language:Chinese
-
Abstract:
Precancerous lesions of gastric cancer is a key stage in the development of gastric cancer.The reprogramming of glucose metabolism is a prominent feature of precancerous lesions of gastric cancer.Hypoxic microenvironment and hypoxia-inducible factors are important factors influencing the occurrence of glucose metabolic reprogramming.This article summarized the relationship between hypoxic microenvironment and the reprogramming of glucose metabolism in precancerous lesions of gastric cancer,and concluded the relevant research on TCM compounds and effective components to improve hypoxic microenvironment and further regulate glycolysis for the treatment of this disease.It was concluded that the mechanism may be the inhibition of angiogenesis,regulation of signaling pathways and key proteins of glycolysis,expression of multiple enzymes,reduction of lactate secretion,inhibition of cell malignant proliferation and invasion.It explored the mechanism of Chinese materia medica in improving hypoxic microenvironment and regulating glycolysis,so as to provide reference for the prevention and treatment of precancerous lesions of gastric cancer.
