A Real-world Study on Bushen Jiedu Huayu Method in the Treatment of Higher-risk Myelodysplastic Syndromes
10.19879/j.cnki.1005-5304.202401415
- VernacularTitle:补肾解毒化瘀法治疗较高危骨髓增生异常综合征的真实世界研究
- Author:
Jian LIU
1
;
Rui LI
;
Xiupeng YANG
;
Hongzhi WANG
;
Yonggang XU
;
Zhuo CHEN
;
Dexiu WANG
;
Haiyan XIAO
;
Xudong TANG
Author Information
1. 北京中医药大学研究生院,北京 100029
- Keywords:
real world;
Bushen Jiedu Huayu Method;
higher-risk myelodysplastic syndromes;
blood routine test;
bone marrow cell morphology
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(9):145-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the performance of routine blood test parameters,bone marrow parameters and the risk factors of leukemia conversion in higher-risk patients with myelodysplastic syndrome(MDS)treated with Bushen Jiedu Huayu Method in the real world.Methods The clinical data of 162 patients with higher-risk MDS who were admitted to the Department of Hematology,Xiyuan Hospital,China Academy of Chinese Medical Sciences from September 2017 to September 2022 were collected,and their clinical data,blood routine parameters,and bone marrow parameters were analyzed.Results A total of 162 higher-risk MDS patients were included,and the overall effective rate of the combination of traditional Chinese and Western medicine treatment,mainly using Bushen Jiedu Huayu Method being 48.8%.Patients with higher-risk MDS who were younger than 70 years old were more likely to obtain curative effect when treated with Bushen Jiedu Huayu Method combined with chemotherapy(P<0.05).After treatment with Bushen Jiedu Huayu Method,PLT levels in higher-risk MDS patients were significantly higher than those before treatment(P<0.05),and PLT levels in the ineffective group increased more significantly(P<0.05).After treatment,the HGB level in the effective group significantly increased(P<0.05).After treatment,the proportion of bone marrow granulocytes,megakaryocytes and lymphocytes in higher-risk MDS patients were significantly higher than those before treatment(P<0.05).Conclusion Bushen Jiedu Huayu Method,mainly using arsenic containing TCM compound,can treat higher-risk MDS.It can increase the HGB content and PLT level of patients,increase the proportion of bone marrow granulocytes,megakaryocytes and lymphocytes,and also play a certain role in reducing the proportion of bone marrow primitive cells,namely demethylation.
