A Case of SLE-systemic Sclerosis Overlap Syndrome Complicated with Nephrotic Syndrome.
- Author:
Bo Young YOON
1
;
Chan Hee LEE
;
Seong Hoon HAN
;
Yun Woo LEE
Author Information
1. Department of Internal Medicine, College of Medicine, Inje University, Korea. byyoon@ilsanpaik.ac.kr
- Publication Type:Case Report
- Keywords:
Systemic sclerosis;
Nephrotic syndrome;
Overlap syndrome
- MeSH:
Adult;
Azotemia;
Biopsy;
Female;
Glomerulonephritis;
Headache;
Humans;
Hypertension;
Nephrotic Syndrome*;
Proteinuria;
Scleroderma, Systemic;
Sclerosis*;
Serum Albumin;
Skin
- From:The Journal of the Korean Rheumatism Association
2004;11(2):174-178
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Renal manifestations of systemic sclerosis are proteinuria, hypertension, azotemia and renal crisis. Mild proteinuria is common, but the nephrotic syndrome occurring in association with systemic sclerosis has been rarely reported. The majority of nephrotic syndrome cases are caused by glomerulonephritis in patients with an overlap syndrome of SLE and systemic sclerosis. This report suggests that the nephrotic syndrome can be an infrequent sequel of systemic sclerosis alone without glomerulopathy. A 38-year old woman was suffering from visual loss and headaches. She had Raynaud's phenomenon and thickened skin on nearly whole body. Urine protein was 4,950 mg/day and serum albumin level was 2.7 g/dL. The result of renal biopsy was renovasculopathy-compatible with systemic sclerosis.
