Analysis on Core Prescriptions and Categorized Prescriptions in TCM for the Treatment of Heart Failure with Preserved Ejection Fraction
10.19879/j.cnki.1005-5304.202402223
- VernacularTitle:中医药治疗射血分数保留心力衰竭的核心处方及类方分析
- Author:
Jingyi LIN
1
,
2
;
Qiguang ZHENG
;
Xiaofei LUO
;
Shuaishuai DENG
;
Xuezhong ZHOU
;
Guanwei FAN
Author Information
1. 天津中医药大学第一附属医院,天津 300381
2. 国家中医针灸临床医学研究中心,天津 300381
- Keywords:
heart failure with preserved ejection fraction;
data mining;
categorized prescription;
complex network
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(8):29-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the medication law of core prescriptions and categorized prescriptions of TCM for the treatment of heart failure with preserved ejection fraction(HFpEF);To provide references for clinical prescriptions of HFpEF.Methods The clinical research literature on TCM for HFpEF was retrieved from CNKI,Wanfang Data,VIP,CBM,PubMed,Web of Science,Embase and Cochrane Library from establishment of the databases to November 1,2023.Data mining methods,such as complex network,prescription similarity network and community detection method were used to explore the prescription medication law of HFpEF.Results Totally 142 articles related to TCM treatment of HFpEF were included,containing 146 prescriptions and involving 162 kinds of Chinese materia medica.The most frequently used drugs were represented by Astragali Radix,Salviae Miltiorrhizae Radix et Rhizoma and Poria.The core prescription and the commonly used modified law of HFpEF treatment were obtained by complex network analysis.The core prescription consisted of Astragali Radix,Poria,Salviae Miltiorrhizae Radix et Rhizoma,Glycyrrhizae Radix et Rhizoma,Chuanxiong Rhizoma,Cinnamomi Ramulus,Descurainiae Semen Lepidii Semen,Atractylodis Macrocephalae Rhizoma,Paeoniae Radix Rubra,Ophiopogonis Radix and Angelicae Sinensis Radix.Further based on the prescription similarity network and community detection method,the basic prescriptions of the 3 major community of categorized prescription corresponding to the HFpEF staging and syndrome types were obtained,and the staged diagnosis and treatment medication law with the development of the HFpEF disease course were found.Conclusion Invigorating qi and activating blood circulation,warming yang and promoting diuresis are the main therapeutic principles of HFpEF.Data mining technology provides a feasible method for the analysis of core prescriptions and categorized prescriptions for HFpEF,which can provide a basis for the diagnosis and treatment law and medication experience of HFpEF in TCM.
