Clinical Efficacy of Shenshuai Ⅱ Prescription Granules Combined with Western Medicine Integrated Treatment on Chronic Kidney Disease Stage 3-4 with Spleen and Kidney Qi Deficiency Syndrome and Its Effects on Renal Microcirculation
10.19879/j.cnki.1005-5304.202401002
- VernacularTitle:肾衰Ⅱ号方颗粒联合西医一体化方案治疗慢性肾脏病3～4期脾肾气虚证患者临床疗效及对肾脏微循环的影响
- Author:
Xinyue ZHANG
1
;
Jing YANG
;
Fang LU
;
Yiling QIAN
;
Chen WANG
Author Information
1. 上海中医药大学附属曙光医院,上海 201203
- Keywords:
chronic kidney disease;
Shenshuai Ⅱ Prescription Granules;
renal microcirculation;
arterial spin labelling imaging;
renal blood flow
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(7):156-161
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect on clinical efficacy and renal microcirculation(RMC)of Shenshuai Ⅱ Prescription Granules in the treatment of patients with stage 3-4 chronic kidney disease(CKD)caused by primary glomerulonephritis(PGN)with deficiency of spleen and kidney qi syndrome.Methods Using a randomized,double-blind clinical trial design,70 patients with CKD stage 3-4 were divided into the treatment group and the control group,with 35 cases in each group.The control group was given CKD integrated treatment combined with placebo granules,and the treatment group was given CKD integrated treatment combined with Shenshuai Ⅱ Prescription Granules.The clinical efficacy of both groups was observed.TCM symptom scores,renal function indexes and RMC indexes before and after treatment of the two groups were compared.Safety indexes of both groups were monitored.Results The total effective rate was 82.86％(29/35)in the treatment group and 54.29％(19/35)in the control group,with statistical significance(P<0.05).Compared with before treatment,all the TCM symptom scores of the 2 groups were reduced after treatment(P<0.05,P<0.01);after treatment,the 5 spleen and kidney qi deficiency symptom scores and the total score of the treatment group were lower than those of the control group(P<0.05).The mean values of renal cortical and medullary blood flow were elevated in the treatment group after treatment compared with the pre-treatment period in this group(P<0.05,P<0.01);the mean values of renal cortical and medullary blood flow were elevated in the treatment group compared with the control group in the post-treatment period(P<0.05,P<0.01).Compared with before treatment,the serum content of NO increased(P<0.01),ET-1 and VEGF decreased(P<0.01);after treatment,the serum content of NO in the treatment group was higher than that in the control group(P<0.05),and ET-1 and VEGF in the treatment group were lower than those in the control group(P<0.01).Compared with before treatment,SCr,BUN,24 hUP decreased and eGFR increased in the treatment group(P<0.05,P<0.01);after treatment,SCr,BUN,and 24 hUP in the treatment group were lower than those in the control group,and eGFR in the treatment group was higher than that in the control group(P<0.01).Compared with this group before treatment and between groups after treatment,the difference in Uric acid between the 2 groups was not statistically significant(P>0.05).There was no abnormal change in safety indexes before and after treatment in both groups(P>0.05).Conclusion Shenshuai Ⅱ Prescription Granules combined with CKD integrated treatment can effectively improve clinical symptoms and renal function related indexes of CKD stage 3-4 patients with spleen and kidney qi deficiency syndrome,increase renal blood flow,improve RMC disorder,and improve clinical efficacy.
