Exploration on the Characteristics of TCM Syndromes in Patients with Coronary Heart Disease Complicated with Hypertension and Diabetes Based on Latent Structure Model
10.19879/j.cnki.1005-5304.202306405
- VernacularTitle:基于隐结构模型探讨冠心病合并高血压糖尿病患者中医证候特征
- Author:
Xin'ang XIAO
1
;
Jieyun LI
;
Yumo XIA
;
Zhaoxia XU
;
Jieqi LIN
;
Yiqin WANG
Author Information
1. 上海中医药大学中医学院,上海 201203
- Keywords:
coronary heart disease;
complications;
latent structure model;
syndrome characteristics
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(7):141-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics of TCM syndromes in patients with coronary heart disease complicated with hypertension and diabetes based on latent structure model.Methods A multi-center cross-sectional study was used to collect the four diagnostic information of patients with coronary heart disease by using the Four Diagnostic Collection Scales of TCM developed by our research group,and a clinical database was established.Combined with frequency analysis and expert opinions,the four diagnostic information was screened to construct a latent structure model.Results Totally 702 patients with coronary heart disease complicated with hypertension and diabetes were collected.A total of 40 high-frequency four-diagnosis symptoms were screened,and 18 latent variables were obtained by latent structure model analysis.The model BIC score was-17 604.38.The latent variables in the model were comprehensively clustered,and it was found that the syndrome elements of disease location in patients with coronary heart disease complicated with hypertension and diabetes were mainly heart,liver,kidney,etc.,and the syndrome elements of disease nature were mainly qi deficiency,yin deficiency,qi stagnation,phlegm turbidity,blood stasis,etc.The syndrome types were mainly phlegm and blood stasis syndrome,spleen and kidney yang deficiency syndrome,liver depression and qi stagnation syndrome,liver and kidney yin deficiency syndrome,damp-heat intrinsic syndrome,and the mutual information and information coverage between each syndrome type and the four diagnostic information were suggested.Conclusion Latent structure model analysis can provide a qualitative and quantitative basis for the syndrome classification of patients with coronary heart disease complicated with hypertension and diabetes.
