Study on the Characteristics of Supramolecular"Imprinting Template"of Curcuma kwangsiensis and Curcuma phaeocaulis
10.19879/j.cnki.1005-5304.202311495
- VernacularTitle:广西莪术和蓬莪术中药超分子"印迹模板"特征研究
- Author:
Weilong ZHANG
1
,
2
,
3
;
Yuchai WANG
;
Ru QIAO
;
Peng HE
;
Shanshan LIANG
;
Sheng LIU
;
Yingyang TAN
;
Yu TANG
;
Limin GONG
;
Fuyuan HE
;
Xue PAN
Author Information
1. 湖南中医药大学药学院,湖南 长沙 410208
2. 中药成药性与制剂制备湖南省重点实验室,湖南 长沙 410208
3. 湖南中医药大学中医药超分子机理与数理特征化实验室,湖南 长沙 410208
- Keywords:
Curcuma kwangsiensis;
Curcuma phaeocaulis;
volatile oil;
supramolecular Chinese materia medica;
imprinting template;
core index;
total statistical moment;
chemometrics
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(6):123-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective The characteristics of supramolecular"imprinting template"of volatile oil of Curcuma kwangsiensis and Curcuma phaeocaulis were analyzed and studied based on the supramolecular"qixi"theory of Chinese materia medica combined with chemometrics.Methods The volatile oil of C.kwangsiensis and C.phaeocaulis were extracted by steam distillation,and the fingerprint and composition information of each batch were obtained by GC-MS.Total statistical moment method was used to compare the imprinting characteristics of the"imprinting template"of C.kwangsiensis and C.phaeocaulis.The core index(CI)of each batch of essential oil of C.kwangsiensis and C.phaeocaulis was calculated,and the topological characteristics of types of"imprinting template"of C.kwangsiensis and C.phaeocaulis were compared by chemometrics.Results There was no significant difference in the extraction rate of volatile oil between C.kwangsiensis and C.phaeocaulis.The average values of total zero order moment(AUCT)were(1.907±0.177)×108,(1.979±0.413)×108 μV·s,respectively,showing that there was no significant difference in the total content of volatile oil between the two groups.The mean values of the total first order moment(MCRTT)were(30.969±0.962)and(33.198±0.409)min.The average value of total second order moment(VCRTT)was(56.176±11.368)and(43.891±4.113)min2,respectively,indicating that there were significant differences in the content ratio and species of volatile oils between the two groups.The similarity of total statistical moments of C.kwangsiensis and C.phaeocaulis was mostly lower than the defined value,indicating that the chemical composition and composition ratio of the volatile oil were different.Principal component analysis and orthogonal partial least squares discriminant analysis could obviously divide C.kwangsiensis and C.phaeocaulis into two categories.Through the analysis of P value and VIP value,the CI values of Xvp 4th order,Xvpc 5th order,Xvpc 6th order,Xvpc 7th order,Xvc 3rd order,Xvpc 4th order were the main difference values of C.kwangsiensis and C.phaeocaulis.Conclusion Through the characterization of"imprinting property"and"topological characteristics"of the supramolecular"imprinting template"and combining with chemometric analysis,it is possible to successfully distinguish C.kwangsiensis and C.phaeocaulis,and find the different CI values between two"imprinting templates".
