Discussion on TCM Etiology and Pathogenesis of Cognitive Dysfunction from the of Perspective Microbiota-gut-brain Axis Based on"Spleen Can't Regulate Spirit"
10.19879/j.cnki.1005-5304.202304097
- VernacularTitle:基于"脾失藏意"从菌群-肠-脑轴探讨认知功能障碍病因病机
- Author:
Lanhui ZHENG
1
;
Qi ZHANG
;
Boyu ZHANG
;
Dandan FENG
;
Jiayao LUO
;
Tong YANG
;
Hua SUI
;
Yan WANG
;
Qingquan SUN
;
Sheng LI
;
Shuyuan LIU
Author Information
1. 大连医科大学中西医结合学院,辽宁 大连 116044
- Keywords:
spleen regulate spirit;
cognitive dysfunction;
microbiota-gut-brain axis;
intestinal flora
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(6):18-23
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive dysfunction refers to dysfunction of individual perception,memory,understanding,learning,creation and other dysfunctions caused by abnormal brain function and structure.Based on the fact that the spleen can't regulate transportation and transformation,govern blood and send up essential substance,combined with the microbiota-gut-brain axis,this article discussed the etiology and pathogenesis of intestinal flora imbalance affecting cognitive dysfunction in TCM.It was proposed that the spleen in TCM and intestinal flora are connected in physiology and pathology:the spleen regulates spirit and governs cognition,when the spleen fails to function normally that it can't dominate transportation and transformation,govern blood and send up essential substance will cause that the brain spirit can not be nourished;intestinal flora is closely related to the spleen in TCM,and affects brain function through the nervous system,endocrine,immune and metabolic mechanisms.This article can provide explore new ideas for the clinical research and treatment of cognitive dysfunction of traditional Chinese and Western medicine.
