Research progress on toxicokinetics and toxicology of chlorfenapyr
10.3969/j.issn.1008-9691.2024.03.028
- VernacularTitle:虫螨腈毒代动力学及毒理学研究进展
- Author:
Hongxin ZHANG
1
;
Zejun MA
;
Yu GONG
;
Na MENG
;
Hao XIAO
;
Liang LIU
;
Baopu LYU
;
Hengbo GAO
;
Yingping TIAN
Author Information
1. 河北医科大学第二医院急诊科,河北石家庄 050000
- Keywords:
Chlorfenapyr;
Tralopyril;
Toxicokinetics;
Toxicology
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2024;31(3):380-384
- CountryChina
- Language:Chinese
-
Abstract:
Chlorfenapyr,an emerging synthetic pesticide,has been linked to a growing number of poisoning incidents,attributed to heightened human exposure as its application becomes more widespread.However,the toxicokinetics and toxicology of chlorfenapyr remain incompletely understood.Research since the 1990s,including animal experiments,has illuminated the absorption,distribution,excretion,and metabolism of chlorfenapyr.Toxicological investigations have revealed that the primary toxicity of chlorfenapyr is the uncoupling of oxidative phosphorylation.Chlorfenapyr exposure in humans and other animals can lead to various toxic effects,including neurotoxicity,cardiotoxicity,skeletal muscle toxicity,genotoxicity,reproductive and developmental toxicity,renal toxicity,splenic toxicity,and hematotoxicity.This article presents a comprehensive review of the toxicokinetics and toxicology of chlorfenapyr,integrating data from animal experiments,human cell line studies,clinical reports,and human autopsy.Its objective is to raise clinical awareness regarding chlorfenapyr poisoning and offer valuable references for its treatment and management.
