Research progress on sepsis-induced immunosuppression
10.3969/j.issn.1008-9691.2024.03.027
- VernacularTitle:脓毒症相关免疫抑制的研究进展
- Author:
Liyuan ZENG
1
;
Xiaoye MO
;
Xiaogang LI
;
Aimin WANG
Author Information
1. 中南大学湘雅医院急诊科,湖南长沙 410008
- Keywords:
Sepsis;
Immunosuppression;
Immunotherapy
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2024;31(3):375-379
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis,characterized by inadequate host responses to infection,leads to life-threatening organ dysfunction and is a major cause of mortality among critically ill patients.Among them,immunosuppression plays a crucial role in the development of sepsis.This review elaborates on the pathogenesis and immunological features of sepsis-induced immunosuppression.Then,we analyzed the current situation of immunotherapy for sepsis from the angles of restoring immune stimulation,eliminating inflammatory mediators,and improving immunity.We emphasized the need for a comprehensive analysis of the traits and immunological types of patients with sepsis,generating new approaches to improve the prognosis of sepsis based on immune targets.
