Anti-Tumor Effect and Anti-Inflammatory Activity of Boschniakia rossica
- Author:
Zong-Zhu YIN
1
;
Hai-Ling JIN
;
Xue-Zhe YIN
;
Ji-Shu QUAN
;
Ming JIN
;
Chun-Mei PIAO
;
Hong-Ying ZHANG
Author Information
1. This work was supported by a grant from the National Natural Science Foundation of China No. 39660021
- From:
Chinese journal of integrative medicine
2001;7(3):2096-213
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the anti-tumor effect and anti-inflammatory activity of Boschniakia rossica (BR). Methods: The expression of tumor marker, GST-P, p53 and p21ras proteins in promotion stage of rat chemical hepatocarcinogenesis were examined by immunohistochemical technique ABC method. Anti-tumor effect of BR was investigated by inhibitory test on Sarcoma180. Anti-inflammatory activity of BR was tested by xylene-induced mouse ear swelling method. Results: BR-H2O extract (the H2O extract fractionated from BR-Methanol extract with CH2Cl2 and H2O) 500 mg/kg has inhibitory effect on the formation of diethylnitrosamine (DEN)-induced glutathione S-transferase placental form (GST-P) positive foci in rat liver with the expression of mutant p53 and p21ras proteins lower than those of non-treated hepatic preneoplastic lesions. BR extract showed inhibitory effect on Sarcoma180 and anti-inflammatory effect in mice by xylene-induced mouse ear swelling tests. Conclusion: BR- H2O extract exerted inhibitory effect on DEN-induced preneoplastic hepatic foci in promotion stage of rat chemical hepatocarcinogenesis and might suppress the growth of solid Sarcoma180 in mice. Both CH2Cl2 and H2O extract from BR exerted anti-inflammatory effect in mice.
