Effect of Emodin on Biological Behavior of Fibroblasts in Lupus Nephritis
- Author:
Guan-Xian LIU
1
;
Ren-Gao YE
;
Zhi-Ming TAN
;
Wei-Qiang ZHONG
;
Yong-Ming YANG
;
Guo-Qiang ZHANG
;
Jing-Ai FANG
Author Information
1. Huizhou Central People's Hospital
- From:
Chinese journal of integrative medicine
2001;7(3):205-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of emodin on the biological behavior of human fibroblasts (FB) in culture of kidney in patients with lupus nephritis (LN). Methods: FB were isolated from kidney culture of LN patients, and the effect of emodin on 3 H-TdR incorporated rate of FB was observed. The apoptosis and c-myc gene expression were detected in the same way by flow cytometry. Results: Emodin could markedly inhibit the proliferation of human kidney FB, and inducing cell apoptosis through up-regulating c-myc gene expression in human renal FB. Conclusion: Emodin can inhibit proliferation and promote apoptosis of FB, which may be important in ameliorating interstitial fibrosis, and thus improve prognosis of LN.
