xperimental Study of Protective Effect of Qingkailing(清开灵) on Brain Damage Induced by Glutamate
- Author:
Shao-Jie YUE
1
;
Pei-Lan YU
;
Zi-Qiang LUO
;
Qing-Shan ZENG
;
Yong-Guang TAO
;
Gan-Qiu WU
Author Information
1. Xiangya Hospital Xiangya Medical College
- From:
Chinese journal of integrative medicine
2001;7(2):112-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective： To observe the effect of Qingkailing (QKL) on brain damage induced by glutamate, in order to seek for effective drugs for antagonizing neurotoxicity of glutamate. Methods：The number and morphological metrology of neurocytes in cerebral cortex and hippocampus were detected by MIAS-300 image analyser, electron microscope and immunohistochemical methods. Results：QKL could alleviate the glutamate induced accumulation of water and sodium in brain tissue，relieve the metrological and structural damage of cerebral cells in cortex and hippocampus, reduce the percentage of c-fos positive cell in brain. Conclusion： QKL could protect brain damage induced by glutamate, which might be related to the inhibition of QKL on the enhancement of c-fos gene expression induced by glutamate.
