Correlation of poorly differentiated cluster grade with clinicopathological features and prognosis of patients with colon cancer
10.12354/j.issn.1000-8179.2024.20240927
- VernacularTitle:结肠癌低分化簇分级与临床病理特征和预后关系的研究
- Author:
Wang XUEZHOU
1
;
Zhu YUNCHAO
;
Wu DEPING
;
Xuan ZILEI
;
Chen XIUMING
;
Zhang XINWEI
Author Information
1. 皖西卫生职业学院附属医院(六安市第二人民医院)肿瘤科(安徽省 六安市 237200)
- Keywords:
colon cancer;
poorly differentiated clusters(PDC);
progression-free survival(PFS);
prognostic stratification
- From:
Chinese Journal of Clinical Oncology
2024;51(18):936-942
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation of poorly differentiated cluster(PDC)grade with clinicopathological features and prognosis of patients with colon cancer.Methods:Hematoxylin-eosin-stained specimens and data from 102 patients with colon cancer who under-went surgery at the Affiliated Hospital of Anhui West Health Vocational College between December 2016 and July 2021 were analyzed in this study.The PDC grades of tumor tissues were determined in all colon cancer cases.Additionally,associations between the PDC grade and clinicopathological features of patients were analyzed via Chi-square test and Logistic regression analysis,whereas the association between the PDC grade and patient prognosis was evaluated using Cox regression analysis.Results:In total,52 cases were identified as PDC G1,14 as PDC G2,and 36 as PDC G3.Tumor budding(TB)was independently and positively associated with PDC,whereas tumor infiltrating lympho-cytes(TIL)were independently and negatively associated with PDC(all P<0.05).Lymph node metastasis or presence of cancerous nodules(hazard ratio[HR]=2.377;95%confidence interval[CI]=1.237-4.568;P=0.009),distant metastasis(HR=7.455;95%CI=2.597-21.399;P<0.001),and the PDC grade(HR=2.095;95%CI=1.099-3.994;P=0.025)were independent risk factors for colon cancer progression.Conclu-sions:Our findings suggest that both TIL and TB affect the colon cancer PDC grade.Therefore,evaluating the PDC grade in cancer tissues can facilitate the prognostic stratification of patients with colon cancer.
