Logic-gated drug delivery systems in cancer immunotherapy
10.12354/j.issn.1000-8179.2024.20240755
- VernacularTitle:逻辑门控递药系统用于肿瘤免疫治疗前沿进展
- Author:
Lin SHUTONG
1
,
2
;
Xie YAXIONG
;
Hou BO
;
Li MIN
;
Yu HAIJUN
Author Information
1. 中国科学院上海药物研究所(上海市 201203)
2. 中国科学院大学
- Keywords:
logic-gated drug delivery;
tumor immunotherapy;
polymer nanoplatform;
nucleic acid logic-gated platform;
chimeric anti-gen receptor T-cell(CAR-T)
- From:
Chinese Journal of Clinical Oncology
2024;51(17):888-895
- CountryChina
- Language:Chinese
-
Abstract:
Immunotherapy has become a mainstream treatment for cancer.However,the immunosuppressive tumor microenvironment hinders the antigen extraction and presentation by immune cells,resulting in insufficient infiltration and activation of cytotoxic T cells.Moreover,patient variability and the systemic distribution of immunotherapeutic agents can cause toxic side effects,such as excessive activ-ation or immunosuppression.The extratumoral toxicity and challenges in penetrating the tumor microenvironment hinder the effectiveness of immunotherapy on solid tumors.Recently,researchers have developed immunotherapy platforms using polymers,nucleic acids,and cells capable of logical processing based on signal inputs.These platforms can target tumors and perform logical processing based on various in-puts from the tumor microenvironment or external signals.This review briefly introduces logic-gated platforms designed using synthetic nanocarriers,nucleic acids,and chimeric antigen receptor T-cells(CAR-T)and discusses research progress in immunotherapy,aiming to provide foresight by comparing the advantages and disadvantages of each platform.
