Advances in the relationship between gut microbiota and colorectal cancer development and treatment
10.12354/j.issn.1000-8179.2024.20240595
- VernacularTitle:肠道菌群和结直肠癌发生发展及治疗的研究进展
- Author:
Shao YUQI
1
;
Hong JIE
Author Information
1. 上海交通大学医学院附属仁济医院消化科,上海市消化疾病研究所(上海市 200001)
- Keywords:
colorectal cancer(CRC);
gut microbiota;
intratumoral microbiota;
immunotherapy;
Fusobacterium nucleatum(F.nucle-atum)
- From:
Chinese Journal of Clinical Oncology
2024;51(17):881-887
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer(CRC),the most common malignant tumor of the digestive system with the highest morbidity and mortality worldwide,has received increasing attention for its relationship with the gut microbiota.The gut microbiota interacts with the host cells to regulate various physiological processes,including metabolism and immune responses.Recently,increasing research has revealed that the interaction between the host and gut microbiota plays a significant role in the origin and progression of CRC.In this review,we discuss the specific mechanisms of the gut microbiota involvement in the carcinogenesis,invasion,and metastasis of CRC,as well as its impact on the therapeutic response and prognosis,by describing the gut and intratumoral microbiota associated with CRC.This information serves as a ref-erence for understanding the relationship between gut microbiota and CRC,and provides therapeutic ideas for the development of microbi-ota-based interventions for CRC treatment.
