Role of RNA modifications in tumor mitochondria:challenges and therapeutic oppor-tunities
10.12354/j.issn.1000-8179.2024.20240625
- VernacularTitle:RNA修饰在肿瘤线粒体中的作用:机遇与挑战
- Author:
Zhou JIAWANG
1
;
Tao LIJUN
;
Wang HONGSHENG
Author Information
1. 中山大学药学院(广州市 510006)
- Keywords:
RNA modification;
tumor;
mitochondria
- From:
Chinese Journal of Clinical Oncology
2024;51(17):873-880
- CountryChina
- Language:Chinese
-
Abstract:
Chemical modifications of nitrogenous bases or ribosemoieties are common in RNA molecules and these RNA modifications regu-late tumor progression by modulating gene expression in malignancies.Therefore,delving into the role of RNA modifications in tumor pro-gression is essential for understanding tumor progression mechanisms and developing intervention strategies.Mitochondria are crucial for maintaining the energy state of malignant tumor cells.Recent studies have indicated that RNA modifications and tumor mitochondria are closely connected,implying that mitochondrial function within tumors can be disrupted due to RNA modifications.This article focuses on the role and underlying mechanisms of RNA modifications in tumor mitochondria,offering crucial insights for a deeper understanding of the reg-ulatory mechanisms of tumor metabolism and the development of new innovative therapeutic strategies.
