The role of m6 A modification in tumor autophagy

VernacularTitle:m6A修饰在肿瘤细胞自噬中的作用
Author: Bai JIE ^{1
,

2} ; Su XIAYI ; Wei XIUZHEN ; Dong YALING ; Zhu ZHIBO ; Zhang BAIHONG
Author Information

1. 甘肃中医药大学第一临床医学院(兰州市 730000)
2. 中国人民解放军联勤保障部队第九四〇医院肿瘤科
Keywords: autophagy; m6A methyltransferases; m6A demethylases; m6A-reading proteins; tumor; drug resistance
From: Chinese Journal of Clinical Oncology 2024;51(15):795-800
CountryChina
Language:Chinese
Abstract: Autophagy is a cellular self-degradation process essential for maintaining metabolic functions in cells and organisms.Dysfunc-tional autophagy has been linked to various diseases,including cancer.The m6A modification,a major RNA modification in eukaryotes,plays a crucial role in regulating autophagy in tumor cells by regulating the expression of autophagy-associated genes(ATGs)or interfering with autophagy-related signaling pathways.Aberrant m6A modification can lead to dysregulated autophagy and impact tumor progression.However,the specific role of m6A in regulating tumor autophagy remains to be explored.Therefore,in this review,we discuss the role of m6A modification in tumor cell autophagy and examine its relationship with tumor progression and drug resistance,aiming to provide a the-oretical foundation for developing new therapeutic strategies.