Research progress on the correlation between chemotherapy efficacy and tumor microenvironment in triple-negative breast cancer

VernacularTitle:三阴性乳腺癌的化疗疗效与肿瘤微环境相关性的研究进展
Author: Huang YUMIAN ^{1
,

2} ; Li HONGYU ; Sun GANG
Author Information

1. 新疆医科大学附属肿瘤医院乳腺甲状腺外科(乌鲁木齐市 830011)
2. 新疆肿瘤学重点实验室
Keywords: triple-negative breast cancer(TNBC); tumor microenvironment(TME); chemotherapy resistance; multi-omics combination
From: Chinese Journal of Clinical Oncology 2024;51(15):785-789
CountryChina
Language:Chinese
Abstract: Triple-negative breast cancer(TNBC)is characterized by tumor heterogeneity and diverse tumor microenvironment(TME),which make its research and treatment more difficult.Chemotherapy is an important TNBC treatment;however,predicting post-treatment effic-acy and chemoresistance remain urgent clinical challenges,with changes in the TME being a major cause.Understanding the facilitating role of the TME is crucial to resolve the challenges.In this study,we assessed the findings of multi-omics studies to explore the research progress on the correlation between the TME and clinical efficacy and chemotherapy resistance of TNBC.We hope to provide a possible direction to improve clinical efficacy and overcome chemotherapy resistance in TNBC.