Endoscopic and pathological analyses of fundic gland-type tumors
10.12354/j.issn.1000-8179.2024.20240870
- VernacularTitle:胃底腺型肿瘤的内镜与病理学分析
- Author:
Chen JIANHUA
1
;
Shi HONG
;
Chen SUYU
;
Huang RUI
;
Lin LILIN
;
Zhang YU
Author Information
1. 福建医科大学肿瘤临床医学院,福建省肿瘤医院消化内镜中心(福州市 350014)
- Keywords:
oxyutic gland adenoma(OGA);
gastric adenocarcinoma of fundic gland type(GA-FG);
MUC6;
endoscopic submucosal dis-section(ESD)
- From:
Chinese Journal of Clinical Oncology
2024;51(15):764-768
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological characteristics of oxyntic gland adenoma(OGA)and gastric adenocarcinoma of the fundic gland type(GA-FG).Methods:Six cases of fundic gland-type tumors(three OGA and three GA-FG)diagnosed at the Fujian Cancer Hospital between August 2020 and February 2023 were retrospectively analyzed.The clinical data,endoscopic features,pathological charac-teristics,immunohistochemical results,treatment,and prognosis were analyzed.Results:Six patients with an average age of 57 years,in-cluding one male and five females,were mainly affected in the gastric fundus and body,with the superficial elevated type being the most common.The pathological features of gastric gland-type tumors are mostly located in the deep layer of the gastric mucosa,showing a dis-ordered glandular structure mainly composed of chief cell-type cells.There were three cases of OGA and three cases of GA-FG.Immunohis-tochemical results showed that pepsinogen 1 was positive in five cases,mucin 6(MUC6)in five cases,synaptophysin(Syn)in six cases,chro-mogranin(CgA)was negative in all cases,and Ki-67 was less than 10%.Conclusions:The incidences of OGA and GA-FG are low,and there is no obvious endoscopic specificity.Endoscopy physicians have an insufficient understanding,which can easily lead to misdiagnoses and missed diagnoses.Immunohistochemistry is helpful for the differential diagnosis,and endoscopic mucosal resection or stripping is the pre-ferred treatment option.
