Correlation of digital breast tomosynthesis and pathological features with the outcome of breast-conserving surgery in early-stage breast cancer
10.12354/j.issn.1000-8179.2024.20240714
- VernacularTitle:数字乳腺断层摄影及病理学特征与早期乳腺癌保乳手术结果的相关性研究
- Author:
Liu LIANGSHENG
1
;
Ma WENJUAN
;
Zhang YU
;
Li YANBO
;
Wang JIAHUI
;
Lu HONG
Author Information
1. 天津医科大学肿瘤医院乳腺影像诊断科,国家恶性肿瘤临床医学研究中心,天津市恶性肿瘤临床医学研究中心,乳腺癌防治教育部重点实验室,天津市"肿瘤防治"重点实验室(天津市 300060)
- Keywords:
breast cancer;
breast-conserving surgery(BCS);
digital breast tomosynthesis(DBT);
image features;
molecular subtype
- From:
Chinese Journal of Clinical Oncology
2024;51(12):611-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between digital breast tomosynthesis(DBT)image features,pathological features,and the results of breast-conserving surgery(BCS)in early stage breast cancer.Methods:We retrospectively analyzed 422 cases of BCS resulting in successful breast preservation and 211 BCS cases that were followed by mastectomy.All of the patients underwent surgery at Tianjin Medical University Cancer Institute&Hospital between January 2019 and December 2023.Preoperative DBT images and clinicopathological features were assessed.A univariate Logistic regression analysis was performed to screen out the characteristics associated with BCS surgic-al results,after which multivariate Logistic regression analysis was performed to screen out the characteristics.Results:Univariate Logistic regression analysis showed that age(P=0.020),architectural distortion(P<0.001),breast composition(extremely dense,P=0.001),and mo-lecular subtype(Her2,P=0.001)were statistically different between the two groups.Multivariate Logistic regression analysis showed that ar-chitectural distortion(P<0.001),breast composition(extremely dense breast,P=0.003),and molecular subtype(Her2,P<0.001)differed signi-ficantly between the two groups.Conclusions:Breast composition,architectural distortion,and molecular subtype correlated with BCS res-ults.Extremely dense breast composition,architectural distortion,and Her2 subtype are associated with a higher possibility of conversion to mastectomy.These factors serve as effective predictive indicators of BCS results and thus aid clinicians in deciding the appropriate surgical strategies in the treatment of breast cancer.
