The role and clinical value of TRMT61A expression in head and neck squamous cell car-cinoma
10.12354/j.issn.1000-8179.2024.20240634
- VernacularTitle:TRMT61A的表达在头颈部鳞状细胞癌中的作用及临床价值
- Author:
Zhao LINGKUN
1
;
Zhou YAOYAO
;
Gong CHENG
;
Li RUI
;
Luo JINGTAO
Author Information
1. 天津医科大学肿瘤医院颌面耳鼻喉肿瘤科,国家恶性肿瘤临床医学研究中心,天津市肿瘤研究所,头颈部肿瘤基础与转化医学重点实验室,天津市"肿瘤防治"重点实验室,天津市恶性肿瘤临床医学研究中心(天津市 300060)
- Keywords:
head and neck squamous cell carcinoma(HNSCC);
tRNA methyltransferase 61A(TRMT61A);
RNA methylation;
cell prolifer-ation
- From:
Chinese Journal of Clinical Oncology
2024;51(12):602-606
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Exploring the role and clinical value of tRNA methyltransferase 61A(TRMT61A)expression in head and neck squam-ous cell carcinoma(HNSCC).Methods:This study analyzed the expression levels of TRMT61A across various cancer tissues and specifically in HNSCC tissues compared to normal head and neck tissues using the Cancer Genome Atlas(TCGA)database.The expression level and pro-gnostic characteristics of TRMT61A in patients with HNSCC were investigated.Furthermore,the proliferation and colony-formation ability of an HNSCC cell line following TRMT61A knockdown was assessed using Western blot,cell counting kit-8(CCK-8),and colony-formation assays.Results:TRMT61A was highly expressed in HNSCC tissues,and its elevated expression significantly correlated with reduced overall survival(OS),progression-free survival(PFS),and disease-specific survival(DSS)in patients.In vitro experiments demonstrated that knocking down TRMT61A suppressed proliferation and the colony-forming ability of HNSCC cells.Conclusions:TRMT61A plays an important role in tumor progression in HNSCC.Targeting TRMT61A expression is a promising approach to affect tumor cell proliferation in HNSCC and is expected to become an effective prognostic indicator for patients with HNSCC.Thus,TRMT61A is a potential therapeutic target for the treatment of HNSCC.
