Research progress of tRNA modifications in gliomas

VernacularTitle:tRNA修饰在胶质瘤中的研究进展
Author: Zhai BEI ¹ ; Wei DENG ; Wang PING
Author Information

1. 中国医科大学神经生物学教研室(沈阳市 110122)
Keywords: glioma; tRNA modification; methylation; tRNA-derived fragment
From: Chinese Journal of Clinical Oncology 2024;51(11):567-571
CountryChina
Language:Chinese
Abstract: tRNA(transfer RNA)is the most highly modified RNA in mammalian cells.Their modifications are highly dynamic and easily af-fected by environmental conditions.Notably,tumor occurrence is often accompanied by abnormal tRNA modifications.Studies have re-vealed abnormal expression of tRNA-modified enzymes in a variety of tumor tissues,thereby associating them to pathogenesis of the dis-ease.Glioma is the most common primary tumor of the central nervous system having the highest incidence of malignancy and poor pro-gnosis.This study provides a comprehensive review of several tRNA modifications associated with gliomas,describing their functions and mechanisms in the occurrence and development of these tumors.We aimed to investigate the potential of aberrantly modified tRNAs and their derivative fragments as biomarkers in glioma diagnosis and propose novel strategies for glioma therapy using small molecule inhibitors that target epigenetic regulatory factors.