Research progress on immunoediting role of tumor-derived exosomes in the microen-vironment of lung cancer
10.12354/j.issn.1000-8179.2024.20231146
- VernacularTitle:肿瘤源性外泌体在肺癌微环境中的免疫编辑作用研究进展
- Author:
Chen QIN
1
,
2
;
Wang JING
;
Jiang RICHENG
;
Qin JIANWEN
Author Information
1. 天津市胸科医院呼吸与危重症医学科(天津市 300050)
2. 天津医科大学肿瘤医院肺部肿瘤内科,国家恶性肿瘤临床医学研究中心,天津市"肿瘤防治"重点实验室,天津肺癌研究中心
- Keywords:
exosome;
lung cancer;
immunoediting;
immune microenvironment
- From:
Chinese Journal of Clinical Oncology
2024;51(10):528-533
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are nanoscale particles secreted by various cells,including immune,stem,and tumor cells.They are enriched with bio-active substances that transport tumor information,mediate intercellular communication,and regulate multiple physiological processes and tumor microenvironment(TME)remodeling.Exosomes secreted by different tumor cell types exhibit cell-specific characteristics,contain various factors involved in immune regulation,and can interact with all types of immune cells.Cancer immunoediting is a process in which the immune system can both constrain and promote tumor development,involving three phases:elimination,equilibrium,and escape.Tu-mor-derived exosomes play diverse roles during these stages,both promoting anti-tumor immunity and inhibiting the anti-tumor activity of immune cells.Collectively,understanding the immunoediting role of exhausted T cells(TEXs)in regulating the immune microenvironment in lung cancer provides novel insights into antitumor therapy.
