Impact of surgical approach on the efficacy and safety of patients with primary central nervous system lymphoma
10.12354/j.issn.1000-8179.2024.20240242
- VernacularTitle:手术方式对原发中枢神经系统淋巴瘤患者疗效和安全性的影响
- Author:
Dai XIANGPING
1
,
2
;
Xue LEI
;
Xu QIANWEN
;
Hu YAN
;
Chen YUANLU
;
Wang XINGBING
Author Information
1. 安徽医科大学附属省立医院血液科(合肥市 230001)
2. 中国科学技术大学附属第一医院(安徽省立医院)血液科
- Keywords:
primary central nervous system lymphoma(PCNSL);
surgical therapy;
efficacy;
safety
- From:
Chinese Journal of Clinical Oncology
2024;51(8):413-417
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of different surgical approaches on the efficacy and safety of patients with primary central nervous system lymphoma(PCNSL).Methods:The clinical data of 130 PCNSL patients admitted to The First Affiliated Hospital of University of Science and Tecnology of China between July 2012 and May 2023 were retrospectively analyzed.Patients were assigned into resection and biopsy groups according to the surgical approach.The safety and efficacy of the two groups were compared,including the objective re-sponse rate(ORR),overall survival(OS),and progression-free survival(PFS)after chemotherapy.Results:ORR and 2-year OS and PFS rates of the resection group were not significantly different from those of the biopsy group(ORR:63.2%vs.62.8%;2-year OS rate:68.6%vs.73.7%;2-year PFS rate:35.2%vs.40.7%,all P>0.05).The incidence of postoperative complications was significantly higher in the resection group than in the biopsy group(29.3%vs.11.4%,P=0.04).The difference in the length of hospitalization between the two groups was not statistic-ally significant.Treatment of the biopsy group was less expensive(P<0.01).Conclusions:In patients with PCNSL,biopsy and resection had comparable efficacy;however,the safety profile was better,and hospitalization was less costly in biopsy than in resection.
