Correlation analysis between MRI parameters and molecular pathology of primary central nervous system lymphoma
10.12354/j.issn.1000-8179.2024.20240023
- VernacularTitle:原发性中枢神经系统淋巴瘤MRI图像参数与分子病理的关联性分析
- Author:
Zhang DONGYANG
1
;
Wang SHUYE
;
Liu YUE
;
Yang KUNPENG
;
Yu HONGJUAN
;
Wang YUE
Author Information
1. 哈尔滨医科大学附属第一医院血液内科(哈尔滨市 150001)
- Keywords:
primary central nervous system lymphoma(PCNSL);
magnetic resonance imaging(MRI);
image parameters;
molecular pathology;
Bruton's tyrosine kinase inhibitor(BTKi)
- From:
Chinese Journal of Clinical Oncology
2024;51(8):401-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigated the relationship between magnetic resonance imaging(MRI)parameters and the molecular pathology of primary central nervous system lymphoma(PCNSL).Methods:We retrospectively analyzed 26 patients from The First Affiliated Hospital of Harbin Medical University between January 2020 and June 2023 classified into germinal center B-cell like(GCB)and non-germinal center B-cell like(non-GCB)groups based on cell origin,into Ki-67≥75%and<75%groups based on the Ki-67 index,into BCL-2+and BCL-2-groups based on BCL-2 expression,and into responsive and non-responsive groups based on their response to MAP+Bruton's tyrosine kinase inhib-itor(BTKi)treatment.We extracted and compared first-order parameters between the groups,including mean value,standard deviation,variance,coefficient of variation,skewness,kurtosis,and entropy from baseline MRI images.Results:Four parameters(variance,kurtosis,skewness,and coefficient of variation)showed no significant differences between groups.However,three parameters(mean,standard devi-ation,and entropy)significantly differed between the groups based on Ki-67 and BCL-2 expression.For the Ki-67 index,the three parameters'areas under the curve(AUC)were 0.731,0.831,and 0.913,respectively.For BCL-2 expression,the mean and standard deviation AUCs were 0.889 and 0.938,respectively.In addition,the mean and entropy parameters significantly differed between the groups categorized by cell origin and treatment responsiveness(P<0.05).Multi-parameter joint analysis demonstrated greater identification accuracy compared to util-izing individual quantitative parameters from texture analysis.Conclusions:The mean,standard deviation,and entropy MRI parameters can help predict Ki-67 and BCL-2 expression in patients with PCNSL and have evaluative functions for treatment.They are beneficial for preoper-ative non-invasive assessment of tumor malignancy,providing vidence for prognosis and treatment planning.
