Research progress on metabolic reprogramming and immune resistance of tumor in-filtrating lymphocytes
10.12354/j.issn.1000-8179.2024.20240439
- VernacularTitle:肿瘤浸润T淋巴细胞代谢重编程与免疫耐药的研究进展
- Author:
Su JIALIN
1
,
2
;
Li YUNING
;
Zhang LEMENG
;
Chen XINGLONG
;
Liu JIASI
;
Jiang ZHOU
;
Luo YONGZHONG
;
Tan SHUHUA
Author Information
1. 湖南科技大学生命科学与健康学院(湖南省湘潭市 411201)
2. 湖南省肿瘤医院胸部内一科
- Keywords:
tumor microenvironment(TME);
tumor infiltrates;
T lymphocytes;
metabolic reprogramming;
immunoresistance
- From:
Chinese Journal of Clinical Oncology
2024;51(7):366-371
- CountryChina
- Language:Chinese
-
Abstract:
Although immunotherapy has made a breakthrough in the treatment of cancer,the emergence of drug resistance has limited be-nefits in most patients,and reversing immunotherapy resistance remains a hotly debated and unresolved issue.The tumor microenviron-ment(TME)comprises a large number of T lymphocytes.During the biological processes of proliferation,activation,and the effect of tumor-infiltrating lymphocytes(TILs),TILs face severe local metabolic stress,resulting in metabolic reprogramming to meet the markedly increased energy demand and biosynthesis requirements.This process of adaptive changes in the metabolic pattern is closely related to the pheno-type and function of TILs,affecting immunotherapy efficacy and mediating immunotherapy resistance.In recent years,with the study of TIL metabolism and the search for specific metabolic regulatory points,targeting the TIL metabolic pathway could restore the tumor-killing func-tion and reverse immunotherapy resistance.This review explores the relationship between the metabolic reprogramming of TILs and im-mune resistance,and provides a new strategy for reversing immune resistance.
