Research on the regulation of energy metabolism-induced ferroptosis in venetoclax resistance in tumor
10.12354/j.issn.1000-8179.2024.20240038
- VernacularTitle:能量代谢调控铁死亡在维奈克拉抗肿瘤耐药中的研究
- Author:
Niu JUNYU
1
;
Huang BINTAO
Author Information
1. 内蒙古医科大学附属医院血液科(呼和浩特市 010059)
- Keywords:
ferroptosis;
venetoclax;
energy metabolism;
drug resistance;
tumor
- From:
Chinese Journal of Clinical Oncology
2024;51(6):313-317
- CountryChina
- Language:Chinese
-
Abstract:
Venetoclax,a BCL-2 inhibitor that induces apoptosis,is primarily employed to treat hematological malignancies and has been shown to substantially improve complete response(CR)in patients with acute myelogenous leukemia(AML).However,with the widespread clinical application of venetoclax,cases of acquired drug resistance have emerged.To address this issue,extensive research has been con-ducted to explore ferroptosis as an alternative programmed cell death pathway that reverses venetoclax resistance.This review discusses the potential mechanisms of acquired resistance to venetoclax in hematological malignancies,provides an overview of several crucial regu-latory pathways associated with abnormal energy metabolism-induced ferroptosis in tumor cells,and summarizes various approaches to modulate energy metabolism in tumor cells to alter ferroptosis and potentially reverse acquired resistance to venetoclax,ultimately guiding the clinical application of venetoclax.
