Research progress on myeloid-derived suppressor cells in multiple myeloma
10.12354/j.issn.1000-8179.2024.20231331
- VernacularTitle:髓源性抑制细胞在多发性骨髓瘤中的研究进展
- Author:
Tang BIN
1
;
Peng XIAOHUAN
;
Xiong HAO
;
Liu JIA
;
Zhu XIAOFENG
;
Li LIJUAN
;
Zhang LIANSHENG
Author Information
1. 兰州大学第二医院血液科(兰州市 730000)
- Keywords:
multiple myeloma(MM);
myeloid-derived suppressor cells(MDSCs);
tumor microenvironment;
reverse of immunosuppres-sion;
angiogenesis
- From:
Chinese Journal of Clinical Oncology
2024;51(6):308-312
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma(MM)is a malignant proliferative disease of plasma cells,ranking as the second most common hematologic tu-mor.Although the use of proteasome inhibitors and immunotherapeutic regimens has improved the prognosis of patients with MM,it re-mains incurable in most patients,mainly because of the eventual development of drug resistance in MM cells.Myeloid-derived suppressor cells(MDSCs)are a heterogeneous group of cells causing significant suppression of the T-cell immune response.They arise from bone mar-row myeloid progenitor cells that are blocked from differentiation and promote MM development by resisting immune destruction.Recent studies indicate that MDSCs stimulate MM cell proliferation,inducing drug resistance and metastasis.In this paper,we review multiple mechanisms exhibited by MDSCs in MM pathogenesis and discuss the feasibility and challenges of current therapeutic strategies targeting MDSCs,aiming to provide pertinent references regarding MM treatment.
