Current research status of lactylation in regulating tumor occurrence and development
10.12354/j.issn.1000-8179.2024.20240211
- VernacularTitle:乳酸化调控肿瘤发生发展的研究现状
- Author:
Zhang BOXING
1
;
Wang SHUKAI
;
Yang HAO
;
Song LIANG
Author Information
1. 陕西中医药大学第二临床医学院(陕西省咸阳市 712046)
- Keywords:
lactylation;
tumor;
post-translational modification
- From:
Chinese Journal of Clinical Oncology
2024;51(5):247-252
- CountryChina
- Language:Chinese
-
Abstract:
Lactylation is a novel lactate-dependent post-translational modification that can alter the structure and function of proteins by covalently coupling lactoyl groups to lysine residues.Therefore,gene expression is regulated and lactylation participates in cellular metabolic and growth processes.Recent studies have shown that lactylation in tumor tissues can affect tumor occurrence and development by regu-lating intracellular signal transduction,gene expression,and protein function.This review summarizes the discovery process of lactylation and recent research progress in tumors,providing novel insights into their prevention and treatment.
