Research progress on the mechanisms of carcinogenic correlation,heterogeneity,and drug resistance of extrachromosomal DNA in small cell lung cancer

VernacularTitle:ecDNA在小细胞肺癌致癌相关性、异质性和耐药性的机制研究进展
Author: Du WEI ¹ ; Lu YAO ; Lu YAXING ; Dong XIUJUAN
Author Information

1. 海南医学院中医学院中西医临床医学系(海口市 571000)
Keywords: extrachromosomal DNA(ecDNA); small cell lung cancer(SCLC); tumor heterogeneity; oncogene amplification; drug resist-ance
From: Chinese Journal of Clinical Oncology 2024;51(4):203-208
CountryChina
Language:Chinese
Abstract: With the progression of research on extrachromosomal DNA(ecDNA),it has been shown that ecDNA exists mainly in tumor cells and plays a crucial role in tumor heterogeneity and drug resistance.ecDNA is observed in several cancer types,but rarely in normal cells.Due to their strong oncogene amplification and dynamic alteration capabilities,patients with ecDNA-containing tumor cells often have negative clinical prognoses.Research has confirmed the presence of ecDNA in the cancer cells of patients with small cell lung cancer(SCLC).This re-view provides a comprehensive summary of the formation mechanism of ecDNA,the processes through which it is amplified in cancer cells,the mechanisms through which ecDNA promotes tumor growth,recurrence,and metastasis,and its relationship with high drug resistance in SCLC.Finally,we generalize the treatment direction for ecDNA-enriched SCLCs,thereby guiding future research.