Application and Progress of Metabolomics in the Etiology of Liver Cancer
10.11735/j.issn.1004-0242.2024.11.A010
- VernacularTitle:代谢组学技术在肝癌病因学研究中的应用与进展
- Author:
Zhuoying LI
1
,
2
,
3
;
Yongbing XIANG
Author Information
1. 复旦大学公共卫生学院,上海 200032
2. 上海交通大学医学院附属仁济医院肿瘤系统医学全国重点实验室,上海 200032
3. 上海市肿瘤研究所流行病学研究室,上海 200032
- Keywords:
metabolomics;
liver cancer;
cohort study;
nested case-control study;
risk factor
- From:
China Cancer
2024;33(11):952-959
- CountryChina
- Language:Chinese
-
Abstract:
Metabolites,as the end products of biochemical reactions within organisms,directly reflect the interplay of gene expression,protein function,and environmental factors,offering a comprehensive reflection of the organism's response to inherent genetic variations and external environmental changes.By systematically analyzing changes in human metabolite profiles,metabolomics aids in the identification of potential biomarkers,offering new insights for the early diagnosis,prevention,and personalized treatment of diseases.In recent years,research method-ologies in metabolomics have increasingly been applied to the etiological studies of liver cancer.This paper aims to review existing research reports to understand the application of metabolomics in the study of liver cancer etiology,with a focus on high-level evidence from prospective cohort studies and case-control studies nested within cohorts.By summarizing the current research evi-dence,the paper aims to advance the study of the etiological mechanisms of liver cancer,under-stand the pathogenic mechanisms of known risk factors,and offer a scientific foundation for the prediction of liver cancer.
