Mitochondrial calcium uniporter and ischemia reperfusion injury

VernacularTitle:线粒体钙离子单向转运蛋白与缺血再灌注损伤
Author: Jiabao GUO ¹ ; Tingting MA ; Huan ZHENG ; Guobin ZHANG ; Jinkun XI
Author Information

1. 华北理工大学临床医学院，唐山　063000
Keywords: Ischemia reperfusion injury; Mitochondrial calcium uniporter; Calcium
From: Clinical Medicine of China 2024;40(5):379-384
CountryChina
Language:Chinese
Abstract: Ischemia reperfusion (I/R) injury is caused by ischemic shock, cardiac arrest, resection and transplantation, and its mechanism is closely related to calcium overload. Mitochondrial calcium uniporter (MCU) is a highly selective calcium channel located in the mitochondrial inner membrane (IMM), mediating calcium ions into the mitochondrial matrix. The MCU complex with the MCU as the core plays an important role in maintaining calcium ion homeostasis and alleviating I/R injury in the heart, kidney, brain, liver and other organs. The mitochondria associated endoplasmic reticulum membranes (MAMs) is a key protein in this process.