Value of MR fat quantification technique in assessing the therapeutic effect of modified Xiaochaihu decoction combined with silymarin capsules for NAfld patients
10.3969/j.issn.1672-8270.2024.09.013
- VernacularTitle:磁共振脂肪定量技术在非酒精性脂肪性肝病患者小柴胡汤加减联合水飞蓟素胶囊治疗疗效评估中的价值
- Author:
Yixi WANG
1
;
Sheng JI
;
Jian GENG
;
Yunhui ZHUO
Author Information
1. 上海中医药大学附属曙光医院肝病科 上海 200120
- Keywords:
Magnetic resonance fat quantification(FQD)technique;
Non-alcoholic fatty liver disease(NAfld);
Xiaochaihu decoction;
Silymarin capsules
- From:
China Medical Equipment
2024;21(9):65-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze application value of magnetic resonance fat quantification(MRFQ)technique in assessing the therapeutic effect of modified Xiaochaihu decoction combined with silymarin capsules for patients with non-alcoholic fatty liver disease(NAfld).Methods:A total of 130 cases of NAfld patients admitted to Shuguang Hospital of Shanghai University of Traditional Chinese Medicine from October 2019 to September 2022 were selected,and they were randomly divided into a control group and an observation group,with 65 cases in each group according to the principle of 1:1 ratio.The control group was treated with silymarin capsules,and the observation group was treated with modified Xiao Chaihu decoction combined with silymarin capsules.Both two groups of patients were examined by FQD technique before and after treatment,and liver fat fraction(F)and proton-density fat fraction(PDFF)before and after treatment were compared between the two groups.The correlation between F value,FDFF value and fatty liver was further analyzed.Result:The total effective rate of the observation group was 96.92%(63/65),while that of the control group was 83.08%(54/65),with a statistically significant difference(x2=6.923,P<0.05).After treatment,the results of FQD technique examination indicated that 35 cases(53.85%)were normal,and 22 cases(33.85%)were mild fatty liver,and 8 cases(12.31%)were moderate fatty liver in 65 cases of observation group,and 24 cases(36.92%)were normal,and 24 cases(36.92%)were mild fatty liver,and 14 cases(21.54%)were moderate fatty liver,and 3 cases(4.62%)were severe fatty liver in 65 cases of control group.The difference of normal rate between the two groups was statistically significant(Z=8.755,P<0.05).After treatment,the body fat(BF),body fat rate(BFR),visceral fat area(VFA),body mass index(BMI)and waist hip ratio(WHR)in the observation group were lower than those in the control group,and the differences were statistically significant(t=6.092,3.991,4.733,5.437,2.413,P<0.05),respectively.After treatment,the F value and PDFF value in the observation group were lower than those in the control group,and the differences were statistically significant(t=9.577,6.589,P<0.05),respectively.With the increasing of the grades of fatty liver,the liver F-value and PDFF value of patients gradually increased.Spearson method was adopted to conduct correlation analysis,and the liver F-value and PDFF value appeared positive correlation with the grades of liver fat(r=0.618,0.648,P<0.05),respectively.Conclusion:FQD technique can find that the liver fat contents of NAfld patients significantly reduce after they receive the modified Xiaochaihu decoction combines with silymarin capsules.The FQD technique can corresponding evaluate the degree of disease condition,which can provide objective reference in evaluating the effect of clinical treatment.
