Relationship between bronchial wall thickness of HRCT examination and the severity and prognosis of chronic obstructive pulmonary disease
10.3969/j.issn.1672-8270.2024.09.008
- VernacularTitle:肺高分辨率CT测定支气管壁增厚与慢性阻塞性肺疾病病情严重程度及其疗效的关系
- Author:
Xuehong LU
1
;
Shuqin KANG
;
Li LUAN
Author Information
1. 新疆医科大学附属中医医院影像中心 乌鲁木齐 830000
- Keywords:
High resolution computed tomography(HRCT);
Bronchial wall thickening;
Chronic obstructive pulmonary disease(COPD);
Pulmonary function;
Correlation
- From:
China Medical Equipment
2024;21(9):38-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between bronchial wall thickness that was determined by high-resolution computed tomography(HRCT)on lung,and pulmonary function and curative efficacy of patients with chronic obstructive pulmonary disease(COPD).Methods:From January 2020 to December 2022,a total of 154 COPD patients were retrospectively selected as the observation group.According to the indicator of the percentage of forced expiratory volume in the first second(FEV1%),the patients were divided into high-risk group(grade Ⅰ,n=51),mild group(grade Ⅱ,n=45),moderate group(grade Ⅲ,n=35)and severe group(grade Ⅳ,n=23)as the 2023 global initiative for chronic obstructive lung disease(GOLD)scale.At the same time,67 healthy subjects were selected as healthy control group.All of them underwent HRCT scan on their chest,and the thickness of the bronchial wall at the opening of the bronchus of bilateral lung apex was measured.The percentage of forced expiratory volume at the first second(FEV1%),forced expiratory volume at the first second(FEV1)and FEV1/forced vital capacity(FEV1/FVC%)(percentage of forced vital capacity)were measured by the pulmonary function apparatus.Pearson correlation analysis software was used to analyze the correlation between bronchial wall thickening and lung function and curative efficacy.Results:The left bronchial wall thickness(1.49±0.21)mm and the right bronchial wall thickness(1.52±0.24)mm in the observation group were higher than those in the healthy control group(t=18.041,15.504,P<0.05),respectively.In the observation group,the higher GOLD grading of the subgroup has higher thickness at the left and right sides of bronchial walls,and there were also significant differences at the thicknesses of bilateral bronchial walls among different grading groups(F=13.888,25.841,P<0.05),respectively.The FEV1(1.82±0.32),FEV1/FVC%(63.09±5.26)and FEV1%(63.36±6.03)in COPD patients of the each subgroup of observation group were lower than those of healthy control group,and the differences were statistically significant(t=6.693,15.392,7.944,P<0.05),respectively.In the observation group,patients with higher GOLD grade has lower decreasing level of the FEV1,FEV1/FVC%and FEV1%,and there were statistically significant differences in pulmonary function levels among the subgroups of the observation group(F=166.541,141.751,57.120,P<0.05),respectively.The results of Pearson correlation analysis showed that the left and right sides of bronchial wall thickening of HRCT scan on COPD patients were positively correlated with FEV1,FEV1/FVC%and FEV1%levels of pulmonary function in COPD patients(r=0.451,0.503,0.498,0.531,0.488.0.515,P<0.05),respectively.Conclusion:The thickness of bronchial wall of HRCT scan images on lung appears high expression in COPD patients,and its expression level can reflect the severity of patients'disease,and has a strong correlation with pulmonary function.
