Placental Apoptosis in Preeclampsia.
- Author:
Won Jun CHOI
1
;
Jeong Gyu SHIN
;
Wan Sung CHOI
;
Jong Hak LEE
;
Won Young PAIK
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Gyeongsang National University, Jinju, Korea. wypaik@gshp.gsnu.ac.kr
- Publication Type:Original Article
- Keywords:
Preeclampsia;
Placenta;
Apoptosis;
Caspase-3
- MeSH:
Apoptosis*;
Caspase 3;
Deoxyuridine;
Female;
Humans;
Immunohistochemistry;
In Situ Nick-End Labeling;
Placenta;
Pre-Eclampsia*;
Pregnancy;
Trophoblasts
- From:Korean Journal of Perinatology
2002;13(3):267-273
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the change of placental apoptosis and the expression of their mediator in preeclampsia women. METHODS: Placental tissues from 10 cases of preeclampsia and 15 cases of normal pregnancy were analyzed using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling(TUNEL) staining. Expressions of bcl-2, bax, caspase-3 was also assessed using immunohistochemistry. RESULTS: In TUNEL staining, the number of apoptotic nuclei were significantly increased in the trophoblast of preeclampsia than normal pregnancy. Bcl-2 was mainly expressed in syncytiotrophoblast and bax was mainly expressed in cytotrophoblast. Bcl-2 expression was decreased and bax expression was increased in the preeclampsia than normal, but the difference was not significant. Caspase-3 was mainly expressed in the cytotrophoblast and expression was significantly increased in the preeclampsia than normal pregnancy(p<0.05). CONCLUSION: Placental apoptosis, especially accompanied with increased expression of caspase-3 in cytotrophoblast, might be related with in the pathogenesis of preeclampsia.
