Application value of color Doppler ultrasound,miR-19a and miR-210 in carotid artery stenosis
10.3969/j.issn.1672-8270.2024.06.015
- VernacularTitle:彩色多普勒超声与miR-19a和miR-210在颈动脉狭窄中的应用价值
- Author:
Hao ZHANG
1
;
Hui WANG
;
Feng XU
;
Shuyan ZHANG
;
Yongfei WEN
;
Zhipei WANG
;
Pengcang DUAN
Author Information
1. 沧州市人民医院超声科 沧州 061000
- Keywords:
Color Doppler ultrasound;
Microribonucleic acid-19a(miR19a);
Microribonucleic acid-210(miR-210);
Carotid stenosis;
Application value
- From:
China Medical Equipment
2024;21(6):76-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the application value of color Doppler ultrasound,microribonucleic acid-19a(miR-19a)and miR-210 in carotid artery stenosis.Methods:A total of 102 patients with carotid artery stenosis who were diagnosed and treated in Cangzhou People's Hospital from October 2020 to October 2022 were selected as the research group,and 102 health persons who underwent color Doppler ultrasound of physical examination in hospital at the same period were selected as the health control group.Both two groups underwent color Doppler ultrasound examination and digital subtraction angiography(DSA)within one week after admitted to hospital.The miR-19a and miR-210 between the two groups were compared,and the miR-19a and miR-210 of patients with different stenosis degrees of research group also were compared.And then,the diagnostic values of color Doppler,miR-19a,miR-210 and the combination of them were analyzed in diagnosing carotid artery stenosis.Results:The results of color Doppler ultrasound in detecting common carotid artery 102 patients of research group indicated that 15 cases were normal,and 15 cases occurred mild stenosis,and 21 cases occurred moderate stenosis,and 21 cases occurred severe stenosis and 33 cases occurred complete occlusion.The miR-19a of the research group was significantly higher than that of the health control group,and the miR-210 of the research group was significantly lower than that of the health control group(t=10.755,-5.903,P<0.05).The miR-19a results of the research group indicated that the miR-19a of mild stenosisthat of moderate stenosis>severe stenosis>complete occlusion,and the differences were statistical significant(F=160.399,147.462,P<0.05),respectively.The receiver operating characteristic(ROC)curve analysis showed that the area under curve(AUC)values of color Doppler ultrasound,miR-19a,miR-210 and combined diagnosis of them for carotid artery stenosis were respectively 0.892,0.842,0.729 and 0.978,and the sensitivity and specificity of the combined diagnosis were respectively 97.1%and 95.1%.Conclusion:The combined diagnosis of color Doppler ultrasound,miR-19a and miR-210 has higher diagnostic value for carotid artery stenosis.
