Contrast-Enhanced Ultrasound in the Differential Diagnosis of Gallbladder Polypoid Lesions:A Multicenter Study
10.3969/j.issn.1005-5185.2024.11.010
- VernacularTitle:超声造影鉴别诊断胆囊息肉样病变性质的多中心研究
- Author:
Ligang JIA
1
,
2
;
Xiang FEI
;
Xiang JING
;
Mingxing LI
;
Fang NIE
;
Dong JIANG
;
Shaoshan TANG
;
Wei ZHANG
;
Hong DING
;
Tao SONG
;
Qi ZHOU
;
Bei ZHANG
;
Zhixia SUN
;
Xiaojuan MA
;
Nianan HE
;
Fang LI
;
Yingqiao ZHU
;
Wen CHENG
;
Yukun LUO
Author Information
1. 解放军总医院第一医学中心超声诊断科,北京 100853
2. 解放军医学院,北京 100853
- Keywords:
Gallbladder polypoid lesion;
Adenomatous polyps;
Cholesterol polyps;
Ultrasonography;
Contrast-enhanced ultrasound;
Diagnosis,differential;
Multicenter study
- From:
Chinese Journal of Medical Imaging
2024;32(11):1147-1154
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the value of contrast-enhanced ultrasound(CEUS)in the differential diagnosis of gallbladder polypoid lesions(GPLs)(diameter≥10 mm).Materials and Methods A prospective enrollment of 229 patients with GPLs who underwent cholecystectomy in 17 hospitals from December 1 2021 to June 30 2024 was conducted to analyze the relationship between general data,conventional ultrasound,CEUS characteristics and the nature of GPLs.Multivariate Logistic regression was employed to identify independent risk factors for neoplastic polyps,the differential diagnostic value of different indicators was compared.Results Among 229 patients with GPLs,there were 108 cases of cholesterol polyps,102 cases of adenoma and 19 cases of gallbladder cancer.Age(Z=-4.476,P<0.001),polyp number(χ2=15.561,P<0.001),diameter(Z=-8.149,P<0.001),echogenicity(χ2=9.241,P=0.010),vascularity(χ2=23.107,P<0.001),enhancement intensity(χ2=47.610,P<0.001),enhancement pattern(χ2=6.468,P=0.011),vascular type(χ2=84.470,P<0.001),integrity of gallbladder wall(χ2=7.662,P=0.006)and stalk width(Z=-9.831,P<0.001)between cholesterol polyps and neoplastic polyps were statistically significant.Age,location,diameter,echogenicity,enhancement pattern,vascular type and stalk width between adenoma and gallbladder cancer were statistically significant(Z=-4.333,-3.902,-5.042,all P<0.05).Multivariate Logistic regression analysis showed that hyper-enhancement,branched vascular type and stalk width were independent risk factors for neoplastic polyps(OR=4.563,5.770,3.075,all P<0.001).The combination of independent risk factors was better than single factor and diameter in the differential diagnosis of cholesterol polyps and neoplastic polyps(all P<0.01).Conclusion CEUS can effectively identify the nature of GPLs and provide a valuable imaging reference for the selection of treatment methods.
