Central Nervous System Injury in Stable Chronic Obstructive Pulmonary Disease Patients by Using Magnetic Resonance Amide Proton Transfer Imaging
10.3969/j.issn.1005-5185.2024.11.003
- VernacularTitle:磁共振酰胺质子转移成像评估稳定期慢性阻塞性肺疾病患者中枢神经系统损伤
- Author:
Gang ZHANG
1
;
Junjing HE
;
Jiemei SUN
;
Lige ZHOU
;
Wei XING
Author Information
1. 河南中医药大学第一附属医院磁共振室,河南 郑州 450000
- Keywords:
Pulmonary disease,chronic obstructive;
Magnetic resonance imaging;
Amide proton transfer weighted imaging;
Central nervous system
- From:
Chinese Journal of Medical Imaging
2024;32(11):1105-1110,1117
- CountryChina
- Language:Chinese
-
Abstract:
Purpose The feasibility and application value of 3D amide proton transfer weighted(APTw)imaging is used to evaluate central nervous system injury in stable chronic obstructive pulmonary disease(COPD)patients.Materials and Methods A total of 36 COPD patients who attended the First Affiliated Hospital of Henan University of Chinese Medicine from January 2022 to August 2023 were selected along with 31 age-and gender-matched healthy volunteers.All subjects underwent pulmonary function tests,routine blood tests,Montreal cognitive assessment scale(MoCA)assessment and 3.0T MRI scan.The APT values of each brain region were measured independently and assessed for consistency by two observers,and the differences in APT values of each brain region were compared between the two groups to explore the correlation between the APT values of multiple brain regions and the pulmonary function,blood indices,and MoCA scores.Results The measurement consistency of APT values in multiple brain regions among observers was good(ICC>0.75).The APT values of brain regions in the COPD group were higher than those in the healthy control group,with statistically significant differences between the bilateral pallidum(t=2.490,2.168),the right thalamus(t=2.754),the nucleus accumbens(t=2.137),the temporal lobe gray matter(t=3.533)and the occipital lobe gray matter(t=2.345)compared with those in the healthy control group(all P<0.05);the APT values of the multiple brain regions were in a negative correlation(r=-0.390--0.084),with a stronger correlation between bilateral pallidum(r=-0.390,-0.370,both P<0.05);lung function indexes(forced vital capacity,forced expiratory volume in one second,forced expiratory volume in one second/forced vital capacity,forced expiratory volume in one second/prediction)in the COPD group showed a negative correlation trend with the APT values of the multibulbar areas(r=-0.339--0.010,all P>0.05),while white blood cell count,red blood cell count,hemoglobin concentration and platelet count showed a positive correlation trend with multi brain APT values(r=0.084-0.587).Conclusion As a novel MRI technology,APTw has potential application value in early detection of central nervous system damage in COPD patients and non-invasive monitoring of disease progression.
