Imaging Findings of Phosphaturic Mesenchymal Tumor
10.3969/j.issn.1005-5185.2024.10.016
- VernacularTitle:磷酸盐尿性间叶性肿瘤影像学表现
- Author:
Juan WANG
1
;
Ying XIONG
;
Weijia WAN
;
Hongquan ZHU
;
Wenzhen ZHU
Author Information
1. 华中科技大学同济医学院附属同济医院放射科,湖北 武汉 430030
- Keywords:
Osteomalacia;
Hypophosphatemia;
Magnetic resonance imaging;
Positron-emission tomography;
Single-photon emission computed tomography;
Fluorodeoxyglucose F18;
Pathology,surgical
- From:
Chinese Journal of Medical Imaging
2024;32(10):1058-1062
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To analyze the multimodal imaging manifestations of phosphaturic mesenchymal tumor.Materials and Methods A retrospective analysis was performed on ten patients with phosphaturic mesenchymal tumor confirmed by pathology and molecular imaging from November 2012 to June 2022 in Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology.The imaging features of CT in four cases,of MRI in seven cases,and of nuclear medicine in ten cases were reviewed,along with the clinical characteristics of all patients.Results The main clinical symptoms of ten patients,eight cases had pain,four cases had weakness,and nine cases had multiple fractures.Laboratory tests results:ten cases showed decreased blood phosphorus,six cases showed decreased blood 25-hydroxyvitamin D and ten cases showed elevated blood alkaline phosphatase.The lesions were heterogeneous in four cases on CT scans and in six cases on MRI scans.Calcification was common,and some had cysts and fatty components.After enhancement,seven cases showed moderate to obvious uneven enhancement.99Tcm-MDP SPECT showed increased uptake of multiple bones and joints in eight cases,18F-FDG PET/CT showed no or slight increase in lesion metabolism in eight cases,68Ga-DOTATATE PET/CT showed significantly high uptake at the lesion site in ten cases.Conclusion Phosphaturic mesenchymal tumor patients typically present with pain,fractures and hypophosphatemia.The conventional imaging features are characterized by small and concealed lesions and complex components.Particularly,68Ga-DOTATATE PET/CT imaging exhibits high sensitivity for the tumor detection.
