Based on Interhemispheric Voxel-Mirrored Homotopic Connectivity and Function Connectivity with the Bilateral Calcarine as the Seed in Observing the Changes of Resting-State Functional MRI in Early Blind Adolescents
10.3969/j.issn.1005-5185.2024.08.003
- VernacularTitle:基于脑镜像同伦功能连接和以双侧距状沟为种子点功能连接观察早盲青少年静息态功能MRI改变
- Author:
Fen HOU
1
;
Hengguo LI
;
Zhifeng ZHOU
;
Bo LI
;
Yuntao HU
;
Xia LIU
Author Information
1. 湖南中医药大学第一附属医院放射科,湖南 长沙 410007
- Keywords:
Voxel-mirrored homotopic connectivity;
Functional connectivity;
Functional magnetic resonance imaging;
Brain function reorganization;
Blind;
Adolescent
- From:
Chinese Journal of Medical Imaging
2024;32(8):767-772
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the changes of interhemispheric functional connectivity and functional connectivity between the selected region of interest(ROI)and other brain areas of the whole brain in resting state in early-blind adolescents(EBAs)via the voxel-mirrored homotopic connectivity(VMHC)and seed-based functional connectivity methods.Materials and Methods A total of 23 EBAs in the Guangdong Province Blind School and 21 age-and gender-matched normal-sighted controls were recruited from June to August 2015.Brain resting-state magnetic resonance imaging scans were performed on all participants.The VMHC were calculated and compared between these two groups.And take the most significant brain area of VMHC as the ROI,the functional connectivity between it and all voxels in the whole brain were calculated and compared,respectively.Results Compared with the control groups,the EBAs groups showed decreased VMHC values in the occipital visual cortex with bilateral calcarine as peak point,bilateral cerebellum and right inferior temporal gyrus(FDR corrected,P<0.05).The EBAs group showed a decreased functional connectivity between bilateral calcarine(brain areas with significantly reduced VMHC),set as ROI and the right cuneus and middle cingulum gyrus,while the enhanced functional connectivity between the bilateral calcarine and the right cerebellum-Crus1 when compared with normal-sighted controls(false discovery rate,FDR corrected,P<0.05).Conclusion The visual cortex interhemispheres mainly in the primary visual cortex of EBAs and its functional connections with multiple brain regions are abnormal,which may indicate abnormal coordination between the primary visual center and other perceptual cortex,and may be related to the brain structure and function remodeling caused by visual loss.
