Application of Magnetic Resonance Diffusion Kurtosis Imaging in Children with Global Developmental Delay
10.3969/j.issn.1005-5185.2024.08.002
- VernacularTitle:磁共振扩散峰度成像在全面发育迟缓患儿中的应用
- Author:
Xiaoxue ZHANG
1
,
2
;
Xin ZHAO
;
Yanyong SHEN
;
Meiying CHENG
;
Shuangyu LI
;
Xiaoan ZHANG
Author Information
1. 郑州大学第三附属医院放射科,河南 郑州 450052
2. 河南神经影像国际联合实验室,河南 郑州 450052
- Keywords:
Developmental disabilities;
Magnetic resonance imaging;
Diffusion kurtosis imaging;
Child
- From:
Chinese Journal of Medical Imaging
2024;32(8):761-766
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe the changes in the brain microstructure of children with global developmental delay(GDD)via MR diffusion kurtosis imaging(DKI).Materials and Methods A total of 34 children with GDD were included as the experimental group,and 34 children with normal development as the control group in the Third Affiliated Hospital of Zhengzhou University from September 2020 to March 2023,retrospectively.DKI and clinical data were collected.After post-processing,DKI parameters were obtained,including fraction anisotropy,mean kurtosis(MK),axial kurtosis and radial kurtosis(Kr).The differences in parameters in each region of interest of the two groups were analyzed,the correlation between DKI parameters and Gesell developmental scale was analyzed,and the receiver operating characteristic curve was drawn to analyze the diagnostic efficacy of DKI parameters.Results Compared with the control group,the MK value of the centrum semiovale decreased(Z=-2.723,P<0.01),the MK value and Kr value of the thalamus decreased(t/Z=-3.220,-3.128,both P<0.01),the MK value and axial kurtosis value of the anterior and posterior limb of internal capsule decreased(t/Z=-2.958,-2.573,-2.085,-2.403,all P<0.05),the Kr value of the anterior limb of internal capsule decreased(t=-2.155,P<0.05),the MK value and Kr value of frontal white matter decreased(Z=-2.177,-2.711,both P<0.05).The correlation analysis showed that the MK and Kr value of the anterior limb of the internal capsule and the MK value of the posterior limb of the internal capsule were positively correlated with the score of the gross motor functional area(r=0.379,0.378,0.405,all P<0.05),and the MK value of the posterior limb of the internal capsule was positively correlated with the fine motor functional area(r=0.461,P=0.006).The Kr value of the thalamus had the largest area under the curve at 0.721 when diagnosing GDD.Conclusion Children with GDD have changes in brain microstructure,and DKI has a certain value for diagnosis.
