Advances in Imaging of Genotype and Targeted Therapy Efficacy of Gastrointestinal Stromal Tumors

VernacularTitle:胃肠道间质瘤基因型及靶向治疗疗效的影像学研究进展
Author: Jiachen SUN ¹ ; Tiezhu REN ; Yuan XU ; Junlin ZHOU
Author Information

1. 兰州大学第二医院放射科,兰州大学第二临床医学院,甘肃省医学影像重点实验室,医学影像人工智能甘肃省国际科技合作基地,甘肃兰州 730030
Keywords: Gastrointestinal stromal tumors; Genotype; Molecular targeted therapy; Radiology; Review
From: Chinese Journal of Medical Imaging 2024;32(7):741-746
CountryChina
Language:Chinese
Abstract: Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract,and they are also genetically heterogeneous tumors.c-KIT gene or PDGFRA gene mutation is the main driving factor leading to its occurrence,and it is also one of the key factors affecting the treatment and prognosis of patients with GISTs.Imaging examination is non-invasive and can display tumors from multiple angles and directions,making it the main method for preoperative evaluation of GISTs.With the continuous development of imaging technology,non-invasive and definite genotyping of GISTs by imaging methods before surgery plays a positive role in the selection of targeted drugs and doses for patients and the evaluation of targeted treatment efficacy.This article reviews the imaging progress on the genotype of GISTs and the efficacy of targeted therapy.