99Tcm-MIBI Bone Uptake on Hungry Bone Syndrome in Renal Hyperparathyroidism After Parathyroidectomy
10.3969/j.issn.1005-5185.2024.07.006
- VernacularTitle:慢性肾病继发性甲状旁腺功能亢进症术后骨饥饿综合征99Tcm-MIBI骨摄取
- Author:
Zejun CHEN
1
;
Bin ZHOU
;
Jingjing FU
;
Chaoqun WU
;
Qing SHAO
;
Qianhuan HUANG
;
Feng WANG
Author Information
1. 南通大学附属江阴医院核医学科,江苏 江阴 214400
- Keywords:
Hyperparathyroidism,secondary;
99Tcm-sestamibi;
Hungry bone syndrome;
Hypocalcemia;
Parathyroid hormone;
Alkaline phosphatase;
Chronic kidney disease-mineral and bone disorder
- From:
Chinese Journal of Medical Imaging
2024;32(7):669-673
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the value of 99Tcm-(methoxyisobutvlisonitrile,MIBI)bone uptake on hungry bone syndrome(HBS)in renal secondary hyperparathyroidism(SHPT)after parathyroidectomy.Materials and Methods From June 2014 to December 2021,106 renal SHPT patients who underwent successful parathyroidectomy in Jiangyin Hospital Affiliated Nantong University were retrospectively enrolled.Visual analysis was used to evaluate the abnormal bone uptake of 99Tcm-MIBI.The patients were divided into HBS group and non-HBS group based on whether occurred HBS.The clinical features,laboratory indicators and 99Tcm-MIBI bone uptake were compared between the two groups.Results Of 106 renal SHPT patients,42(39.62%)patients with bone uptake on visual assessment,showed diffusely increased tracer accumulation,particularly in sternum,clavicle and ribs.The age in HBS group was younger than that in non-HBS group(t=-3.058),the alkaline phosphatase and parathyroid hormone level in HBS group were higher than that in non-HBS group(Z=-5.148,-2.218),the serum corrected calcium in HBS group was lower than that in non-HBS group(Z=-2.102),the positive rate and number of 99Tcm-MIBI bone uptake in HBS group was 50%and 2(1,3),which was higher than that of 28%and 1(1,1)in non-HBS group(χ2=5.344,Z=-2.970),respectively,all showed statistically significant difference(all P<0.05).Conclusion Renal SHPT patient with HBS after parathyroidectomy is commonly related to a high level of alkaline phosphatase and parathyroid hormone,and more likely to develop abnormal 99Tcm-MIBI bone uptake.
