Adenosine Stress Myocardial Perfusion Imaging in Evaluating Myocardial Ischemia in Kawasaki Disease
10.3969/j.issn.1005-5185.2024.06.011
- VernacularTitle:腺苷负荷心肌灌注显像评估川崎病心肌缺血的价值
- Author:
Yiwei LI
1
;
Ruifang ZHAO
;
Yanli SHEN
;
Leijun SHI
;
Lite XU
;
Biying ZHANG
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院核医学科,上海 200062
- Keywords:
Mucocutaneous lymph node syndrome;
Coronary artery disease;
Myocardial ischemia;
Myocardial perfusion imaging;
Children
- From:
Chinese Journal of Medical Imaging
2024;32(6):587-590,598
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the safety and clinical value of adenosine stress myocardial perfusion imaging(MPI)in evaluating myocardial ischemia in children with Kawasaki disease.Materials and Methods A total of 78 children with a history of Kawasaki disease and coronary artery aneurysm confirmed by echocardiography and coronary angiography were prospectively studied in Children's Hospital of Fudan University from August 2019 to February 2021.Adenosine stress MPIs were performed to analyze the safety of adenosine stress test and its sensitivity and specificity in detecting significant coronary artery stenosis(≥75%),and the positive rate of adenosine stress MPIs in different groups of coronary artery stenosis were further compared.Results All 78 children completed adenosine stress test without serious side effects.Among 78 children with adenosine stress imaging,44 patients with negative adenosine stress imaging did not undergo rest imaging,which reduced radiation exposure by 56.4%(44/78).The sensitivity and specificity of adenosine stress MPIs in detecting significant coronary artery stenosis were 66.7%and 60.6%(40/66),respectively.Adenosine stress MPIs were positive in 21 cases(21/52,40.3%)in non-stenosis group,5 cases(35.7%)in mild to moderate stenosis group,and 8 cases(66.7%)in significant stenosis group.There was no significant difference in the positive rate among the three groups(χ2=3.169,P=0.205).Conclusion Adenosine stress test is safe and feasible in children.The stress-first imaging strategy can reduce radiation exposure.Adenosine stress MPI has important clinical value in evaluating and monitoring myocardial ischemia in children with Kawasaki disease complicated with coronary aneurysm.
